Bronidox (5-bromo-5-nitro-1,3-dioxane) cas 30007-47-7

Bronidox (5-bromo-5-nitro-1,3-dioxane)
CAS:30007-47-7
MF:C4H6BrNO4
MW:212

Bronidox (5-bromo-5-nitro-1,3-dioxane),cas 30007-47-7, is an antimicrobial chemical compound.
Bronidox causes inhibition of enzyme activity in bacteria.
Bronidox is corrosive to metals.

Synonyms:
Bronidox
m-DIOXANE
BND
BRONIDOX
BRONIDOX L
MicrocideItm
5-bromo-5-nitro-m-dioxan
5-Bromo-5-nitro-m-dioxane
5-bromo-5-nitro-3-dioxane
5-Brom-5-nitro-1,3-dioxan
3-Dioxane,5-bromo-5-nitro-1
5-BROMO-5-NIT
m-Dioxane, 5-bromo-5-nitro-

Properties of Bronidox (5-bromo-5-nitro-1,3-dioxane),cas 30007-47-7
Physical State (20 deg.C): crystalline solid
Melting point:58-60 °C
Boiling point:280.8±40.0 °C(Predicted)
Density 1.070
Refractive index 1.6200 (estimate)
Solubility
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
Ethanol: 25 mg/ml
Vapour Pressure:0.0±0.6 mmHg at 25°C

Application of Bronidox (5-bromo-5-nitro-1,3-dioxane),cas 30007-47-7
Bactericide
Fungicide, effective against yeast and other fungi[citation needed]
It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use
of sodium azide.
Stabilizer
Surfactant
Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
Some users do not recommend use in preparations destined for in vivo or tissue culture work

Storage of Bronidox (5-bromo-5-nitro-1,3-dioxane),cas 30007-47-7
Stability:≥ 2 years
storage temp. 2-8°C

Reference:
【1】Ya. Legin, G. 2-Bromo-2-nitro-1,3-propanediol(Bronopol) and its derivatives: Synthesis, properties, and application (a review).
Pharmaceutical Chemistry Journal. 1996, 30, (4), 273-284.
【2】Ghannoum, M.; Thomson, M.; Bowman, W.; Al-Khalil, S. Mode of action of the antimicrobial compound 5-Bromo-5-nitro-1,3-dioxane
(Bronidox). Folia Microbiologica. 1986, 31, (1), 19-31.
【3】 5-BROMO-5-NITRO-1,3-DIOXANE Archived March 3, 2016, at the Wayback Machine, chemicalland21.com
【4】"Archived copy" (PDF). Archived from the original (PDF) on September 29, 2007. Retrieved March 19, 2006.
【5】Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane
(bronidox)". Folia Microbiol. (Praha). 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729.

 

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