emeramide protocol
Formulation emeramide protocol:
1. Gadde R, Betharia S. N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells. Arch Toxicol. 2021 Aug;95(8):2643-2657. doi: 10.1007/s00204-021-03103-2. Epub 2021 Jun 24. PMID: 34165617. 2. Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. PMID: 21994240; PMCID: PMC3503146. 3. Ke T, Bornhorst J, Schwerdtle T, Santamaría A, Soare FAA, Rocha JBT, Farina M, Bowman AB, Aschner M. Therapeutic Efficacy of the N,N' Bis-(2-Mercaptoethyl) Isophthalamide Chelator for Methylmercury Intoxication in Caenorhabditis elegans. Neurotox Res. 2020 Jun;38(1):133-144. doi: 10.1007/s12640-020-00194-0. Epub 2020 Mar 31. PMID: 32236898; PMCID: PMC7924665. 4. Nilsson JLÅ, Blomgren A, Nilsson UJ, Högestätt ED, Grundemar L. N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity. Basic Clin Pharmacol Toxicol. 2018 Nov;123(5):589-593. doi: 10.1111/bcpt.13058. Epub 2018 Jul 9. PMID: 29908097.
In vitro protocol of emeramide:
1. Gadde R, Betharia S. N N'bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells. Arch Toxicol. 2021 Aug;95(8):2643-2657. doi: 10.1007/s00204-021-03103-2. Epub 2021 Jun 24. PMID: 34165617. 2. Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. PMID: 21994240; PMCID: PMC3503146.
In vivo emeramide protocol:
1. Ke T, Bornhorst J, Schwerdtle T, Santamaría A, Soare FAA, Rocha JBT, Farina M, Bowman AB, Aschner M. Therapeutic Efficacy of the N,N' Bis-(2-Mercaptoethyl) Isophthalamide Chelator for Methylmercury Intoxication in Caenorhabditis elegans. Neurotox Res. 2020 Jun;38(1):133-144. doi: 10.1007/s12640-020-00194-0. Epub 2020 Mar 31. PMID: 32236898; PMCID: PMC7924665. 2. Nilsson JLÅ, Blomgren A, Nilsson UJ, Högestätt ED, Grundemar L. N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity. Basic Clin Pharmacol Toxicol. 2018 Nov;123(5):589-593. doi: 10.1111/bcpt.13058. Epub 2018 Jul 9. PMID: 29908097.