HOPO Chelator,cas 110874-36-7,Chelating agent for Gadolinium,Radioactive elements Plutonium,americium,Zirconium-89

HOPO Chelator,cas 110874-36-7,Chelating agent for Gadolinium,Radioactive elements Plutonium,americium,Zirconium-89

Use:
1. therapeutic metal chelating agent for Environmental contaminants like lead and cadmium
2. therapeutic metal chelating agent for Gadolinium that deposits in the body after exposure to MRI contrast agents
3. therapeutic metal chelating agent for Radioactive elements such as plutonium, americium, and other actinides
4. Spermine-based hydroxypyridonate octadentate chelator 3,4,3-LI(1,2-HOPO) has great potential as a therapeutic metal chelating agent.
5. Ultimate Chelator HOPO for Zirconium-89 (89Zr) based PET imaging agents.

MF:C34H38N8O12
MW:750.71

 

 

 

 

 

Synonyms:
HOPO,KUN74367,KUN-74367,N,N'-1,4-Butanediylbis(N-(3-(((1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl)amino)propyl)-1,6-dihydro-1-hydroxy-6-oxo-2- pyridinecarboxamide,hydroxypyridonate,LiHOPO,treatment of Gadolinium Poisoning,Gd Poisoning,Gadolinium chelating agent,Gadolinium Chelator,hopo chelator drug for Uranium (U),hopo chelator drug for Gadolinium (Gd),3 4 3-LI(1 2-HOPO) to reduce Uranium (U),3 4 3-LI(1 2-HOPO) to reduce Plutonium (Pu),3 4 3-LI(1 2-HOPO) to reduce Americium (Am),hopo chelator drug for Plutonium (Pu),hopo chelator drug for Americium (Am),Chelator for Environmental contaminants like lead and cadmium,therapeutic metal chelating agent for Environmental contaminants like lead and cadmium,therapeutic metal chelating agent for Gadolinium,therapeutic metal chelating agent for Gadolinium,Chelator for Radioactive elements plutonium,Chelator for Radioactive elements americium,Chelator for Radioactive elements other actinides,therapeutic metal chelating agent for Radioactive elements plutonium, therapeutic metal chelating agent for Radioactive elements americium,therapeutic metal chelating agent for Radioactive elements other actinides,HOPO Chelator-removal of Gd based contrast agents,HOPO Chelator-removal of gadolinium-based contrast,HOPO Chelator -How to remove gadolinium from the body,HOPO Chelator -detox gadolinium,HOPO Chelator -gadolinium detox,HOPO Chelator -Gd detox,HOPO Chelator -Remove Gadolinium From Brain And Body Tissue,HOPO Chelator-Treatment Possibilities for Gadolinium Toxicity,HOPO Chelator-how to chelate gadolinium,HOPO Chelator-how to prevent gadolinium toxicity,HOPO Chelator-gadolinium toxicity treatment,HOPO Chelator-who treats gadolinium poisoning,HOPO Chelator-how to remove gadolinium from the brain,HOPO Chelator-how to get gadolinium out of your system,HOPO Chelator-how to remove gadolinium from the body,buy HOPO Chelator,HOPO Chelator buy,Gadolinium Retention,Zirconium-89 Chelator HOPO,hopo chelator for Gadolinium-based contrast agents toxicity,hopo chelator to cure Gadolinium-based contrast agents poisoning,HOPO chelation for gadolinium,Gadolinium toxicity treatment by HOPO Chelator,HOPO Chelator for Gadolinium (Gd),HOPO Chelator treats gadolinium poisoning,HOPO Chelating agent for gadolinium,Gadolinium deposition disease treatment by HOPO Chelator,Gadolinium chelation therapy with HOPO Chelator,

Properties:
Appearance: Solid powder
Solubility: Soluble in DMSO
Drug Formulation: This drug may be formulated in DMSO
Purity:  95%+;   98%+

 

Introduction
3,4,3-Li(1,2-HOPO) is a very efficient ligand to remove actinides from the body after simulated contamination.and It has been
evaluated for potential biomedical applications; thus, toxicology and pharmacology studies have already been completed. In addition,
the in vivo stability of metal complexes of 3,4,3-Li(1,2-HOPO)formed with both trivalent (Eu, Am, Cm) and tetravalent (Zr, Pu)
metals has been investigated in multiple studies, using ex vivo radioanalytical techniques and in vivo PET imaging.

 

Probably 3,4,3-LI(1,2-HOPO) become a therapeutic chelating agent for gadolinium, which is used in MRI contrast agents. (chelation therapy in patients exposed to gadolinium-based contrast agents)

 

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks
during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0-4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Shelf Life: >3 years if stored properly
HS Tariff Code: 2934.99.9001

 

Experiment and Practice
3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7 is known to have high affinity for both trivalent and tetravalent lanthanide and actinide cations. Here we extend its coordination chemistry to the rare-earth cations Sc3? and Y3? and characterize fundamental metal-chelator binding interactions in solution via UV-Vis spectrophotometry, nuclear magnetic resonance spectroscopy, and spectrofluorimetric metal-competition titrations, as well as in the solid-state via single crystal X-ray diffraction. Sc3? and Y3? binding with3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7 is found to be robust, with both high thermodynamic stability and fast room temperature radiolabeling, indicating that 3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7 is likely a promising chelator for in vivo applications with both metals. So the potential of 343-HOPO chelated trivalent metal cations for therapeutic and theranostic applications.

Siderophore-inspired multidentate hydroxypyridonate ligands can be used in a variety of applications such as magnetic resonance imaging (MRI) contrast enhancement, lanthanide luminescence sensitization, and iron and actinide chelation.The octadentate ligand 3,4,3-LI(1,2-HOPO), composed of four 1-hydroxy-pyridin-2-one (1,2-HOPO) units linked to a spermine scaffold through amide linkages, is currently considered the most efficient experimental decorporation agent for actinides.Studies have shown that this ligand is orally active and is by far more efficacious than the commonly used diethylenetriamine-pentaacetic acid at promoting the in vivo decorporation of actinide metal ions, such as UVI, NpV, PuIV, and AmIII.In addition, 3,4,3-LI(1,2-HOPO) is known to act as an antenna that sensitizes the luminescence of EuIII, a feature that was used recently to determine the solution thermodynamic stability of the corresponding [EuIII(3,4,3-LI(1,2-HOPO))]? complex. In the work presented here, the photophysical properties of the complexes of 3,4,3-LI(1,2-HOPO) formed with metal ions from the whole lanthanide series were probed and characteristic emission sensitization was observed in both the Visible and Near Infra-Red ranges, depending on the complexed metal ion. The use of the antenna effect as a spectroscopic tool was extended to spectrofluorimetric competition titrations, to determine the formation constants of these lanthanide complexes. While such thermodynamic parameters are essential to characterize 3,4,3-LI(1,2-HOPO) as a chelating agent and compare its affinity to different metal ions, they are only indicative of the potential in vivo decorporation efficacy of the
ligand. The in vivo EuIII complex stability and EuIII decorporation capacity of 3,4,3-LI(1,2-HOPO) were therefore also assessed in mice, using the radioactive isotope 152Eu as a contaminant, which provides a direct comparison with the in vitro thermodynamic results.

The high affinity of this chelator for lanthanides, as compared to DTPA, indicates its potential as a therapeutic chelating agent for f-block metal ions, which was confirmed through the first in vivo decorporation and stability experiments using the radiotracer 152Eu, a common fission product in the nuclear fuel process. Other radionuclides potentially targeted by 3,4,3-LI(1,2-HOPO) include tri- and tetravalent actinides such as Pu(IV) and Am(III). The analytical methods used here will be applied to the determination of the photophysical properties and thermodynamic parameters of the corresponding 3,4,3-LI(1,2-HOPO) complexes, providing a rationale to the use and design of new decorporation agents. In addition, sensing f-block metal ions through luminescence spectroscopy has the potential to ease and significantly improve current actinide detection and characterization methods in terms of selectivity and accuracy.

 

How do you get rid of gadolinium naturally?
Use HOPO Chelator.

Can you chelate gadolinium?
Yes, HOPO Chelator is most advanced and highly selective Chelator.

What is used to chelate gadolinium?
HOPO Chelator (3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7)

How do you get gadolinium toxicity?
For any patients exposed to gadolinium-based contrast agents will get Gadolinium toxicity.

 

how to chelate gadolinium ?
Use HOPO Chelator (3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7)

how to flush out mri contrast dye?
Use HOPO Chelator (3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7)

how to flush kidneys after mri?
Use HOPO Chelator (3,4,3-Li(1,2-HOPO) CAS No.: 110874-36-7).

dtpa chelation for gadolinium ?
it is not good one, in fact very bad.
HOPO Chelator is most advanced and highly selective Chelator.

 

References
1. P. W. Durbin, Health Phys., 2008, 95, 465-492.
2. K. Djanashvili and J. A. Peters, Contrast Media Mol. Imaging, 2007, 2, 67-71.
3. E. G. Moore, A. P. S. Samuel, and K. N. Raymond, Acc. Chem. Res., 2009, 42, 542-552.
4. R. C. Scarrow, P. E. Riley, K. Abu-Dari, D. L. White, and K. N. Raymond, Inorg. Chem., 1985, 24, 954-967.
5. E. J. Werner, A. Datta, C. J. Jocher, and K. N. Raymond, Angew. Chem. Int. Ed., 2008, 47, 8568-8580.
6. R. J. Abergel, P. W. Durbin, B. Kullgren, S. N. Ebbe, J. Xu, P. Y. Chang, D. I. Bunin, E. A. Blakely, K. A. Bjornstad, C. J.
Rosen, D. K. Shuh, and K.
E. G. Moore, C. J. Jocher, J. Xu, E. J. Werner, and K. N. Raymond, Inorg. Chem., 2007, 46, 5468-5470.
N. Raymond, Health Phys., 2010, 99, 401-407.
7. P. W. Durbin, B. Kullgren, S. N. Ebbe, J. Xu, and K. N. Raymond, Health Phys., 2000, 78, 511.
8. R. J. Abergel and K. N. Raymond, Hemoglobin, 2011, 35.
9. R. J. Abergel, A. D’Aleo, C. Ng Pak Leung, D. K. Shuh, and K. N. Raymond, Inorg. Chem., 2009, 48, 10868-10870.
10. P. Gans and B. O’Sullivan, Talanta, 2000, 51, 33-37.
11. A. Heller, A. Barkleit, and G. Bernhard, Chem. Res. Toxicol., 2011, 24, 193-203.
12. P. Gans, A. Sabatini, and A. Vacca, HYPERQUAD2000, Leeds, U.K. Florence, Italy.
13. P. Gans, A. Sabatini, and A. Vacca, Talanta, 1996, 43, 1739-1753.
14. P. Gans, A. Sabatini, and A. Vacca, Ann. Chim., 1999, 89, 45-49.
15. P. Gans, A. Sabatini, and A. Vacca, HypSpec, Leeds, U.K. Florence, Italy.

Comment

related information

3,3′-DISULFONATED-4,4′-DIFLUOROPHENYL SULFONE, DISODIUM SALT cas 301155-59-9

2021-12-06 Fine Chemicals

3,3'-DISULFONATED-4,4'-DIFLUOROPHENYL SULFONE, DISODIUM SALT cas 301155-59-9 MF:C12H6F2Na2O8S3 MW:458.34 Synonyms: Disodium4,4'-difluorodiphenylsulfone-3,3'-disulfonate;3,3'-DISULFONATED-4,4'-DIFLUOROPHENYLSULFONE,DISODIUMSALT;3,3Chemicalbo…

Omicure BC-120 (Boron Trichloride Amine Complex) cas 34762-90-8

2021-11-29 Fine Chemicals

Omicure BC-120 (Boron Trichloride Amine Complex) CAS:34762-90-8 MF:C10H23BCl3N MW:274.46632 Synonyms: BTD, BCL3:DMOA, lewis acid accelerator, Latent Curing Agent, Accelerator, 3M Scotch-Weld EC-3450 FST, DY 9577, EPOXYLITE 577, Araldite DY …

Quaterfolic (GlucosaMine L-5-Methyltetrahydrofolate) cas 1181972-37-1

2021-11-29 Fine Chemicals

Quaterfolic (GlucosaMine L-5-Methyltetrahydrofolate) cas 1181972-37-1 MF:C26H38N8O11 MW:638.62692 Suppliers of GlucosaMine L-5-Methyltetrahydrofolate cas 1181972-37-1: GNOSIS S.p.A; FandaChem Synonyms: 5MTHF-glucosamine, Levomefolic acid, Q…

Gadolinium Poisoning, Gadolinium Toxicity

2021-11-26 Fine Chemicals

Gadolinium Poisoning, Gadolinium Toxicity Most of the known toxicity of the free Gd3+ ion is related to 2 properties: its insolubility at physiologic pH, resulting in very slow systemic excretion; and an ionic radius close to that of Ca2+ (…

Gadolinium side effects

2021-11-26 Fine Chemicals

Gadolinium side effects GBCAs and MRIs Gadolinium-based contrast agents (GBCAs) are soluble metal-ligand complexes of gadolinium ion Gd3+. Contrast agents fall into the definition of drugs as a tool for making a medical diagnosis [1]. GBCAs…

Ultimate Chelator HOPO for Zirconium-89 (89Zr) based PET imaging agents

2021-11-25 Fine Chemicals

Ultimate Chelator HOPO for Zirconium-89 (89Zr) based PET imaging agents Zirconium-89 is an effective radionuclide for antibody-based positron emission tomography (PET) imaging because its physical half-life (78.41 h) matches the biological …

Medkoo Emeramide Price

2021-11-22 Fine Chemicals

Medkoo Emeramide Price 5g:    USD 150 10g:  USD 250 20g:  USD 450 Medkoo Emeramide Residual Solvent Class 2: DMF (Dimethyl Formamide) MedKoo CAT#: 319633 CAS#: 351994-94-0 CAS#: 351994-94-0 Chemical Formula: C12H16N2O2S2 Exact Mass: 284.065…

Detox gadolinium from my body? – HOPO chelator

2021-11-20 Fine Chemicals

How should I detox gadolinium from my body? We have found that chelation therapy and the use of specific oral supplements is the best treatment for most patients. Chelation is especially valuable – a procedure which uses a specific binding …

Sodium Lauroamphoacetate 35%,Miranol Ultra L-32,Cola Teric L-32,cas 68608-66-2

2021-11-18 Fine Chemicals

Sodium Lauroamphoacetate 35%,Miranol Ultra L-32,Cola Teric L-32,cas 68608-66-2 MF:C18H36ClN2Na2O4+ MW:425.92198 CAS:68608-66-2 Synonyms: Miranol Ultra L-32 Cola Teric L-32 Colateric SLAA MIRANOL HMD Lauroamphoacetate SLA Sodium Lauroamphoac…

Miglyol 840 (Propylene Glycol Dicaprylate/Dicaprate),cas no 77466-09-2;68583-51-7

2021-11-18 Fine Chemicals

Miglyol 840 (Propylene Glycol Dicaprylate/Dicaprate),cas no 77466-09-2;68583-51-7 Synonyms: CAPTEX 200 CRODAMOL PC ESTOL 1526 MIGLYOL 840 MYRITOL PC Myritol PGDC SABODERM PGDD Caprylic/Capric Fatty acids, C8-10, propylene esters PROPYLENE G…