Miglyol 812 (Capry/Capric Triglyceride) cas 37332-31-3
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Chemical & Physical Properties of Miglyol 812 (Capry/Capric Triglyceride) cas 37332-31-3
Appearacne：Colorless or slightly yellowish oily liquid.
Odour: faint odour
Melting point range: < 0 °C cloudpoint
Flash point: 220 °C (DIN ISO 2592)
Vapour pressure: (20 °C) < 0,01 hPa
Density: (20 °C) 0,93 – 0,96 g/cm3
Water: < 1g/l (20 °C)
Viscosity, dynamic: (20 °C) 25-33 mPas
saponification value：≥100–135mg KOH/g
hydrophilic lipophilic balance：12~14(HLB)
MIGLYOL 812 N is soluble at 20°C in the following solvents:
Hexane, toluene, diethyl ether, ethyl acetate, acetone, isopropanol and ethanol 96%. MIGLYOL 812 N is miscible in all ratios with natural oils.
MIGLYOL 812 N is not soluble in water and glycerol.
Introduction of Miglyol 812 (Capry/Capric Triglyceride) cas 37332-31-3
What is Miglyol 812?
Miglyol 812 is composed of 55% triglycerides of C8 and 45% triglycerides of C10 fatty acids.Miglyol 812 is also a clear neutral oil. Miglyol 812 is a liquid form of an MCT oil. An MCT oil is a medium-chain triglyceride. A medium-chain triglyceride is a man-made fat that is partially manmade. It is identified by the way the carbon atoms are rearranged in the structure. Many people use MCTs, which are typically derived from coconut and palms oils and dairy fats, for improved diet and weight management.
According to the Cleveland Clinic, MCTs decrease metabolic syndrome, reduce abdominal obesity, and boost weight loss. Like miglyol 840, miglyol 812 is desired in toxicology and pharmaceuticals because it improves the solubility and absorption of injectables and oral compounds. Miglyol is soluble at 20 degrees Celsius. Additional properties of miglyol 812 are spreadability, penetration-promoting application, and high stability compared to natural oils. When used as a lotion, cream, or any other spreadable application, miglyol 812 is permeable and non-greasy; therefore, it does not obstruct the skin’s natural respiration.
Whether you use miglyol 812 or miglyol 840, it is recommended you filter the oil before use, even if you buy directly from the manufacturer. It is better to err on the side of caution. Even if the miglyol sold online says it is made with raw materials and is already filtered, always take the extra step yourself to ensure you get any contaminants out. While natural oils may seem like a better solution for your needs, it is important to consider miglyol compounds because they are manufactured in a way that ensures stability and purity. They can also be more cost effective.
MIGLYOL 812 N is very pure because of its carefully selected raw materials. As a result of tightly controlled manufacturing process microorganisms are practically absent because of very low levels of water, i.e. microbials cannot sustain. It is free of additives such as antioxidants, solvents and catalyst residues.
Miglyol 812 (Capry/Capric Triglyceride) cas 37332-31-3 has the following advantages compared to edible oils:
- low in impurities (as a result of production according to EU GMP guidelines)
- high stability against oxidation
- liquid at 0°C
At low temperatures parts of the triglycerides may crystallize. This phenomenon is completely reversible.
Miglyol 812 (Capry/Capric Triglyceride) cas 37332-31-3 Applications
Tablets, dragees: Anti-sticking, polishing agents.
Soft gelatine capsules: Chemically neutral, low-viscosity carrier oil, absorption promoter.
Drops: Carrier, solvent, and absorption promoter.
Suspensions, syrups: Carrier and absorption promoter for antibiotics etc.
Aerosol products: Carrier and solvent (glycerol trinitrate etc.).
Dietetic products & Nutraceuticals: Medium chain triglycerides (MCT) differ from natural fats (LCT). With regard to these essential properties: quick metabolism, not stored as body fat.
Physiological caloric value = 8,2 kcal/g (34,3 kJ/g) compared with LCT = 9,2 kcal/g (38,5 kJ/g).
1）Natl Toxicol Program Tech Rep Ser. 2010 Sep;(560):1, 7-31,33-171 passim.
2）Reynir Eyjolfsson, in Design and Manufacture of Pharmaceutical Tablets, 2015
3）Atul Awasthi, ... Sanjay Garg, in Profiles of Drug Substances, Excipients and Related Methodology, 2013
4）Jutta Kockler, ... Beverley D. Glass, in Profiles of Drug Substances, Excipients and Related Methodology, 2013