Quaterfolic (GlucosaMine L-5-Methyltetrahydrofolate) cas 1181972-37-1

Quaterfolic (GlucosaMine L-5-Methyltetrahydrofolate)
cas 1181972-37-1
MF:C26H38N8O11
MW:638.62692

Suppliers of GlucosaMine L-5-Methyltetrahydrofolate cas 1181972-37-1:
GNOSIS S.p.A;
FandaChem

Synonyms:
5MTHF-glucosamine,
Levomefolic acid,
Quaterfolic,
levomefolate glucosamine,
L-5-Methyltetrahydrofolate glucosamine,
(6S)-5-methyltetrahydrofolic acid, glucosamine salt
GlucosaMine L-5-Methyltetrahy,
GlucosaMine tetrahydrofolic acid salt,
GlucosaMine L-5-Methyltetrahydrofolate,
L-5-Methyltetrahydrofolate glucosamine,
(6S)-5-methyltetrahydrofolic acid Glucosamine salt,Quaterfolic substitute,

Appearance: White powder
pH (1% w/v aqueous solution):5.5 - 6.5
Solubility:ery soluble in water; soluble in dilute acid and dilute alkali; Practically insoluble in most organic solvents.
Specific optical rotation (dry, 10% w/v in water):+53° to +59
Refractivity: 121.93 m3·mol-1

Application of Quaterfolic (GlucosaMine L-5-Methyltetrahydrofolate)
*nutrition additive
Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods
and in the blood circulation, accounting for 98% of folates in human plasma 8. It is transported across the membranes including the
blood-brain barrier into various tissues where it plays an essential role in the DNA synthesis, cysteine cycle and regulation of
homocysteine, where it methylates homocysteine and forms methionine and tetrahydrofolate (THF). Levomefolate is approved as a food
additive and is designated a GRAS (generally regarded as safe) compound 13. It is available commercially as a crystalline form of
the calcium salt (Metafolin(R)), which has the stability required for use as a supplement 8. Supplementation of levomefolic acid is
desired over folic acid due to reduced potential for masking vitamin B12 deficiency symptoms.
*pharmaceutical intermediate

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